Which security measure should be implemented to isolate applications and reduce potential threats?

Implementing sandboxing as a security measure is an effective way to isolate applications and mitigate potential threats. Sandboxing allows applications to run in a controlled environment that is separate from the main operating system and other applications. This controlled environment limits the access of the application to system resources, thus reducing the risk of potentially malicious behavior affecting the overall system.

By confining an application in a sandbox, even if it is compromised, the attacker would have limited access to the system's resources, reducing their ability to cause harm or exfiltrate sensitive data. This is particularly useful for testing untrusted applications or executing potentially dangerous files without risking the integrity of the host system.

In contrast, other security measures, while important, serve different purposes. Patch management involves regularly updating software to fix vulnerabilities but doesn’t provide the isolation that sandboxing does. Network segmentation helps limit the spread of threats within different parts of a network but does not address the isolation of individual applications on a host. Firewall configurations focus on controlling incoming and outgoing network traffic but do not isolate applications on the same system level. Thus, sandboxing offers a targeted approach to encapsulating and controlling individual applications, making it the most suitable choice for isolating applications and reducing potential threats.